abstract：:Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease caused by an abnormal expansion of a tandem CAG repeat in exon 1 of the androgen receptor (AR) gene that results in an abnormally long polyglutamine tract (polyQ) in the AR protein. As a result, the mutant AR (ARpolyQ) misfolds, forming cytopl...

journal_title：Neurobiology of aging

authors： Rusmini P,Crippa V,Giorgetti E,Boncoraglio A,Cristofani R,Carra S,Poletti A

更新日期：2013-11-01 00:00:00

abstract：:Amyloid beta (Aβ) is implicated in Alzheimer's disease (AD) as an integral component of both neural toxicity and plaque formation. Brains of the longest-lived rodents, naked mole-rats (NMRs) approximately 32 years of age, had levels of Aβ similar to those of the 3xTg-AD mouse model of AD. Interestingly, there was no e...

journal_title：Neurobiology of aging

authors： Edrey YH,Medina DX,Gaczynska M,Osmulski PA,Oddo S,Caccamo A,Buffenstein R

更新日期：2013-10-01 00:00:00

abstract：:Next-generation sequencing was used to investigate 9 rare Chinese pedigrees with rare autosomal recessive neurologic Mendelian disorders. Five probands with ataxia-telangectasia and 1 proband with chorea-acanthocytosis were analyzed by targeted gene sequencing. Whole-exome sequencing was used to investigate 3 affected...

journal_title：Neurobiology of aging

authors： Chen Z,Wang JL,Tang BS,Sun ZF,Shi YT,Shen L,Lei LF,Wei XM,Xiao JJ,Hu ZM,Pan Q,Xia K,Zhang QY,Dai MZ,Liu Y,Ashizawa T,Jiang H

更新日期：2013-10-01 00:00:00

abstract：:The vervet is an old world monkey increasingly being used as a model for human diseases. In addition to plaques and tangles, an additional hallmark of Alzheimer's disease is damage to neurons that synthesize noradrenaline (NA). We characterized amyloid burden in the posterior temporal lobe of young and aged vervets, a...

journal_title：Neurobiology of aging

authors： Kalinin S,Willard SL,Shively CA,Kaplan JR,Register TC,Jorgensen MJ,Polak PE,Rubinstein I,Feinstein DL

更新日期：2013-10-01 00:00:00

abstract：:The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent...

journal_title：Neurobiology of aging

authors： Ting SK,Chong MS,Kandiah N,Hameed S,Tan L,Au WL,Prakash KM,Pavanni R,Lee TS,Foo JN,Bei JX,Yu XQ,Liu JJ,Zhao Y,Lee WL,Tan EK

更新日期：2013-10-01 00:00:00

abstract：:Flexible instrumental learning is required to harness the appropriate behaviors to obtain rewards and to avoid punishments. The precise contribution of dopaminergic midbrain regions (substantia nigra/ventral tegmental area [SN/VTA]) to this form of behavioral adaptation remains unclear. Normal aging is associated with...

journal_title：Neurobiology of aging

authors： Chowdhury R,Guitart-Masip M,Lambert C,Dolan RJ,Düzel E

更新日期：2013-10-01 00:00:00

abstract：:The increased life expectancy of people living with HIV-1/AIDS is accompanied by increased prevalence of HIV-1-associated neurocognitive disorder. As well, these individuals are increasingly experiencing Alzheimer's disease (AD)-like neurocognitive problems and neuropathological features such as increased deposition o...

journal_title：Neurobiology of aging

authors： Chen X,Hui L,Geiger NH,Haughey NJ,Geiger JD

更新日期：2013-10-01 00:00:00

abstract：:We investigated whether individuals with impaired glucose tolerance (IGT) in midlife subsequently show regionally specific longitudinal changes in regional cerebral blood flow (rCBF) relative to those with normal glucose tolerance (NGT). Sixty-four cognitively normal participants in the neuroimaging substudy of the Ba...

journal_title：Neurobiology of aging

authors： Thambisetty M,Beason-Held LL,An Y,Kraut M,Metter J,Egan J,Ferrucci L,O'Brien R,Resnick SM

更新日期：2013-10-01 00:00:00

abstract：:In simple systems, lifespan can be extended by various methods including dietary restriction, mutations in the insulin/insulin-like growth factor (IGF) pathway or mitochondria among other processes. It is widely held that the mechanisms that extend lifespan may be adapted for diminishing age-associated pathologies. We...

journal_title：Neurobiology of aging

authors： Tauffenberger A,Julien C,Parker JA

更新日期：2013-09-01 00:00:00

abstract：:The ability to perceive and produce speech undergoes important changes in late adulthood. The goal of the present study was to characterize functional and structural age-related differences in the cortical network that support speech perception and production, using magnetic resonance imaging, as well as the relations...

journal_title：Neurobiology of aging

authors： Tremblay P,Dick AS,Small SL

更新日期：2013-08-01 00:00:00

abstract：:Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing fu...

journal_title：Neurobiology of aging

authors： Nolan LS,Maier H,Hermans-Borgmeyer I,Girotto G,Ecob R,Pirastu N,Cadge BA,Hübner C,Gasparini P,Strachan DP,Davis A,Dawson SJ

更新日期：2013-08-01 00:00:00

abstract：:We conducted genetic analysis of the fused in sarcoma gene (FUS) in Chinese Han patients with essential tremor (ET) in a case-control association study. One hundred eighty unrelated patients with ET were screened for mutations in the coding region and exon-intron boundaries of FUS. Reverse transcriptase polymerase cha...

journal_title：Neurobiology of aging

authors： Zheng W,Deng X,Liang H,Song Z,Gao K,Yang Y,Deng H

更新日期：2013-08-01 00:00:00

abstract：:A major goal of animal research is to identify interventions that can promote successful aging and delay or reverse age-related cognitive decline in humans. Recent advances in standardizing cognitive assessment tools for humans have the potential to bring preclinical work closer to human research in aging and Alzheime...

journal_title：Neurobiology of aging

authors： Snigdha S,Milgram NW,Willis SL,Albert M,Weintraub S,Fortin NJ,Cotman CW

更新日期：2013-07-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian disorder. Abnormal tau inclusions, in selected regions of the brain, are a hallmark of the disease and the H1 haplotype of MAPT, the gene encoding tau, is the major risk factor in PSP. A 3-repeat and 4-repeat (4R) tau isoform ratio imbalance...

journal_title：Neurobiology of aging

authors： Majounie E,Cross W,Newsway V,Dillman A,Vandrovcova J,Morris CM,Nalls MA,Ferrucci L,Owen MJ,O'Donovan MC,Cookson MR,Singleton AB,de Silva R,Morris HR

更新日期：2013-07-01 00:00:00

abstract：:Positron emission tomography (PET) has been used extensively to evaluate the neuropathology of Alzheimer's disease (AD) in vivo. Radiotracers directed toward the amyloid deposition such as [(18)F]-FDDNP (2-(1-{6-[(2-[F]Fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile) and [(11)C]-PIB (Pittsburg compound ...

journal_title：Neurobiology of aging

authors： Rojas S,Herance JR,Gispert JD,Abad S,Torrent E,Jiménez X,Pareto D,Perpiña U,Sarroca S,Rodríguez E,Ortega-Aznar A,Sanfeliu C

更新日期：2013-07-01 00:00:00

abstract：:The internal carotid artery termination (CAT) ends in a T-shaped bifurcation just below the substantia innominata (SI), which contains cognitively strategic cholinergic neurons and undergoes atrophy in Alzheimer's disease (AD). This study investigated whether an elongated CAT with possible resulting encroachment into ...

journal_title：Neurobiology of aging

authors： Gao FQ,Pettersen JA,Bocti C,Nestor SM,Kiss A,Black SE

更新日期：2013-07-01 00:00:00

abstract：:Alzheimer's disease is characterized by amyloid plaques, neurofibrillary tangles, glial activation, and neurodegeneration. In mouse models, inflammatory activation of microglia accelerates tau pathology. The chemokine fractalkine serves as an endogenous neuronal modulator to quell microglial activation. Experiments wi...

journal_title：Neurobiology of aging

authors： Nash KR,Lee DC,Hunt JB Jr,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D

更新日期：2013-06-01 00:00:00

abstract：:Large repeat expansions in the C9orf72 gene were recently reported to be a major cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. Given some of the clinical and pathologic overlap between these 2 diseases and Parkinson's disease, we sought to evaluate the presence of these expansions in a c...

journal_title：Neurobiology of aging

authors： Daoud H,Noreau A,Rochefort D,Paquin-Lanthier G,Gauthier MT,Provencher P,Pourcher E,Dupré N,Chouinard S,Jodoin N,Soland V,Fon EA,Dion PA,Rouleau GA

更新日期：2013-06-01 00:00:00

abstract：:The Asp620Asn mutation in the vacuolar protein sorting protein 35 (VPS35) gene and the Arg1205His mutation in the eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) gene were identified in autosomal dominant late-onset familial and sporadic Parkinson disease (PD) patients in a Caucasian population. However, t...

journal_title：Neurobiology of aging

authors： Chen Y,Chen K,Song W,Chen X,Cao B,Huang R,Zhao B,Guo X,Burgunder J,Li J,Shang HF

更新日期：2013-06-01 00:00:00

abstract：:Studies in asymptomatic granulin gene (GRN) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinic...

journal_title：Neurobiology of aging

authors： Moreno F,Sala-Llonch R,Barandiaran M,Sánchez-Valle R,Estanga A,Bartrés-Faz D,Sistiaga A,Alzualde A,Fernández E,Martí Massó JF,López de Munain A,Indakoetxea B

更新日期：2013-05-01 00:00:00

abstract：:Neuronal inclusions of α-synuclein (α-syn), termed Lewy bodies, are a hallmark of Parkinson disease (PD). Increased α-syn levels can occur in brains of aging human and neurotoxin-treated mice. Because previous studies have shown increased brain lactate levels in aging brains, in PD affected subjects when compared with...

journal_title：Neurobiology of aging

authors： Jiang P,Gan M,Ebrahim AS,Castanedes-Casey M,Dickson DW,Yen SH

更新日期：2013-05-01 00:00:00

abstract：:Oligomers of beta-amyloid (Aβ) are implicated in the early memory impairment seen in Alzheimer's disease before to the onset of discernable neurodegeneration. Here, the capacity of a novel orally bioavailable, central nervous system-penetrating small molecule 5-aryloxypyrimidine, SEN1500, to prevent cell-derived (7PA2...

journal_title：Neurobiology of aging

authors： O'Hare E,Scopes DI,Kim EM,Palmer P,Jones M,Whyment AD,Spanswick D,Amijee H,Nerou E,McMahon B,Treherne JM,Jeggo R

更新日期：2013-04-01 00:00:00

abstract：:Although neuroactive steroids exert neuroprotective actions in different experimental models of neurodegenerative diseases, including those of Alzheimer's disease (AD), their relationships with aged related physiologic and pathologic brain changes remain to be clarified. In this study the levels of pregnenolone, dehyd...

journal_title：Neurobiology of aging

authors： Caruso D,Barron AM,Brown MA,Abbiati F,Carrero P,Pike CJ,Garcia-Segura LM,Melcangi RC

更新日期：2013-04-01 00:00:00

abstract：:Mutations in the profilin 1 (PFN1) gene, encoding a member of the profilin family of small actin-binding proteins, have been recently reported in patients with familial amyotrophic lateral sclerosis (ALS). In this study we aimed to determine the prevalence of PFN1 mutations by sequencing the coding region of this gene...

journal_title：Neurobiology of aging

authors： Daoud H,Dobrzeniecka S,Camu W,Meininger V,Dupré N,Dion PA,Rouleau GA

更新日期：2013-04-01 00:00:00

abstract：:Alzheimer's disease (AD) involves progressive neurodegeneration in the presence of misfolded proteins and poorly-understood inflammatory changes. However, research has shown that AD is genetically, clinically, and pathologically heterogeneous. In frozen brain samples of frontal cortex (diseased) and cerebellum (nondis...

journal_title：Neurobiology of aging

authors： Sudduth TL,Schmitt FA,Nelson PT,Wilcock DM

更新日期：2013-04-01 00:00:00

abstract：:Perisynaptic accumulations of amyloid β-protein (Aβ) play a critical role in the synaptic dysfunction underlying the cognitive impairment observed in Alzheimer's disease. The methionine residue at position 35 (Met35) in Aβ is highly subject to oxidation in Alzheimer's disease brains. In hippocampal brain slices we fou...

journal_title：Neurobiology of aging

authors： Ripoli C,Piacentini R,Riccardi E,Leone L,Li Puma DD,Bitan G,Grassi C

更新日期：2013-04-01 00:00:00

abstract：:APOE is the major known genetic risk factor for late-onset Alzheimer's disease. Though relationships between APOE-encoded apolipoprotein E and β-amyloid are increasingly well described, mounting evidence supports wide-ranging effects of APOE on the brain. Specifically, APOE appears to affect brain network activity and...

journal_title：Neurobiology of aging

authors： Wolf AB,Caselli RJ,Reiman EM,Valla J

更新日期：2013-04-01 00:00:00

abstract：:Arousal and valence play key roles in emotional perception, with normal aging leading to changes in the neural substrates supporting valence processing. The objective of this study was to investigate normal age-related changes in the neural substrates of emotional arousal processing. Twenty-three young and 23 older, h...

journal_title：Neurobiology of aging

authors： Kehoe EG,Toomey JM,Balsters JH,Bokde AL

更新日期：2013-03-01 00:00:00

abstract：:Estrogens have been implicated as possible therapeutic agents for improving cognition in postmenopausal women and have been linked to neurodegenerative disorders such as Alzheimer's disease. However, the utility of Premarin (Wyeth Pharmaceuticals, Markham, ON, Canada), a conjugated equine estrogen and the most commonl...

journal_title：Neurobiology of aging

authors： Barha CK,Galea LA

更新日期：2013-03-01 00:00:00

abstract：:Accumulation of disease-related proteins is a characteristic event observed in the pathogenesis of neurodegenerative diseases. β-secretase (BACE)-1, which initiates generation of β-amyloid (Aβ), is increased in the Alzheimer's diseased brain. However, the mechanisms of BACE1 accumulation in Alzheimer's disease are lar...

journal_title：Neurobiology of aging

authors： Yun SM,Cho SJ,Song JC,Song SY,Jo SA,Jo C,Yoon K,Tanzi RE,Choi EJ,Koh YH

更新日期：2013-03-01 00:00:00

abstract：:Using resting state (RS) functional magnetic resonance imaging and independent component analysis, the integrity of brain networks related to cognition and behavior was investigated in 20 nondemented patients with amyotrophic lateral sclerosis (ALS). The association between RS functional connectivity and executive fun...

journal_title：Neurobiology of aging

authors： Agosta F,Canu E,Valsasina P,Riva N,Prelle A,Comi G,Filippi M

更新日期：2013-02-01 00:00:00

abstract：:Type 2 diabetes mellitus is a risk factor of Alzheimer's disease (AD), most likely linked to an impairment of insulin signaling in the brain. Liraglutide, a novel long-lasting glucagon-like peptide 1 (GLP-1) analog, facilitates insulin signaling and shows neuroprotective properties. In the present study, we analyzed t...

journal_title：Neurobiology of aging

authors： Han WN,Hölscher C,Yuan L,Yang W,Wang XH,Wu MN,Qi JS

更新日期：2013-02-01 00:00:00

abstract：:The mitochondrial theory of aging argues that oxidative stress, caused by mitochondrial DNA mutations, is associated with decreased adenosine triphosphate (ATP) production leading to cellular degeneration. The rate of this degradation is linked to metabolic demand, with the outer retina having the greatest in the body...

journal_title：Neurobiology of aging

authors： Kokkinopoulos I,Colman A,Hogg C,Heckenlively J,Jeffery G

更新日期：2013-02-01 00:00:00

abstract：:Apolipoprotein E (APOE) ε4 is a major risk factor for Alzheimer's disease (AD) and dementia, but not all ε4 carriers develop dementia. We sought to identify factors that may play a role in modifying the risk of dementia due to ε4. A cognitively intact cohort (n = 932, age ≥ 75) was followed for 9 years to detect incid...

journal_title：Neurobiology of aging

authors： Ferrari C,Xu WL,Wang HX,Winblad B,Sorbi S,Qiu C,Fratiglioni L

更新日期：2013-01-01 00:00:00

abstract：:This study modeled predementia Alzheimer's disease clinical trials. Longitudinal data from cognitively normal (CN) and mild cognitive impairment (MCI) participants in the Alzheimer's Disease Neuroimaging Initiative were used to calculate sample size requirements for trials using outcome measures, including the Clinica...

journal_title：Neurobiology of aging

authors： Grill JD,Di L,Lu PH,Lee C,Ringman J,Apostolova LG,Chow N,Kohannim O,Cummings JL,Thompson PM,Elashoff D,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2013-01-01 00:00:00

abstract：:The gap between symptoms and pathology in Alzheimer's disease has been explained by the hypothetical construct of "cognitive reserve"--a set of variables including education, intelligence, and mental stimulation which putatively allow the brain to adapt to-and hence mask--underlying pathologies by maintaining cognitiv...

journal_title：Neurobiology of aging

authors： Robertson IH

更新日期：2013-01-01 00:00:00

abstract：:Medial temporal lobe atrophy (MTA) and cerebrospinal fluid (CSF) markers of Alzheimer's disease (AD) pathology may aid the early detection of AD in mild cognitive impairment (MCI). However, the relationship between structural and pathological markers is not well understood. Furthermore, while posterior atrophy (PA) is...

journal_title：Neurobiology of aging

authors： Lehmann M,Koedam EL,Barnes J,Bartlett JW,Barkhof F,Wattjes MP,Schott JM,Scheltens P,Fox NC,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2013-01-01 00:00:00

abstract：:CR1 is a novel Alzheimer's disease (AD) gene identified by genome-wide association studies (GWAS). Recently, we showed that AD risk could be explained by an 18-kilobase insertion responsible for the complement component (3b/4b) receptor 1 (CR1)-S isoform. We investigated the relevance of the CR1 isoforms to AD in a Ca...

journal_title：Neurobiology of aging

authors： Hazrati LN,Van Cauwenberghe C,Brooks PL,Brouwers N,Ghani M,Sato C,Cruts M,Sleegers K,St George-Hyslop P,Van Broeckhoven C,Rogaeva E

更新日期：2012-12-01 00:00:00

abstract：:People with obesity and type 2 diabetes are at increased risk of cognitive impairment. We aimed to investigate the association of leptin with cognitive abilities in an elderly population with type 2 diabetes. We performed a cross-sectional study of 1057 men and women aged 60-75 years with type 2 diabetes living in Lot...

journal_title：Neurobiology of aging

authors： Labad J,Price JF,Strachan MW,Deary IJ,Seckl JR,Sattar N,Reynolds RM,Edinburgh Type 2 Diabetes Study Investigators.

更新日期：2012-12-01 00:00:00

abstract：:The accumulation of β-amyloid (Aβ) peptide derived from abnormal processing of amyloid precursor protein (APP) is a common pathological hallmark of Alzheimer's disease (AD) brains. In this study, we evaluated the therapeutic effect of berberine (BBR) extracted from Coptis chinensis Franch, a Chinese medicinal herb, on...

journal_title：Neurobiology of aging

authors： Durairajan SS,Liu LF,Lu JH,Chen LL,Yuan Q,Chung SK,Huang L,Li XS,Huang JD,Li M

更新日期：2012-12-01 00:00:00